Harvest leaves or whole young plants for fresh use. Harvest black seeds when ripe and dry for medicinal use.

Note: Epazote self-sows readily. May become invasive, if allowed to do so.
 
The epazote herb is commonly used in the cuisines and traditional medicines of central and southern Mexico and Guatemala. Epazote has a strong taste and aroma, so not everyone takes to it right away. It can be somewhat of an acquired taste, but it adds a wonderful rustic layer of flavor to many dishes. While it is best to use fresh epazote, the dried form can be used if no fresh herbs are available. The peak season for the herb is in winter, but it is available year-round.
 
What Is Epazote? 
Epazote (pronounced eh-pah-ZOH-teh) is an aromatic herb; both the fresh leaves and tender stems are used in cooking. The epazote plant is a leafy annual or short-lived perennial plant that can reach 4 feet in height. Its dark green, long, slender, jagged leaves end in a point. The flowers are green and very small; they produce thousands of tiny seeds. As an herb, it is suitable for gluten-free, vegan, vegetarian, and paleo diets.